While the Toyota Sequoia is generally praised for its reliability and durability, there are some model years that have been associated with certain issues to be cautious of. In particular, the first-generation models produced from 2001 to 2007 have been noted for potential problems with the transmission and suspension components, as well as some issues with rust and interior quality. However, it's worth noting that Toyota has continuously improved the Sequoia over the years, and later model years, especially from 2008 onwards, tend to have fewer reported issues. Overall, while there may be certain years to approach with caution, the Sequoia remains a solid choice for those seeking a reliable and capable full-size SUV. Regular maintenance and thorough inspection before purchasing can help mitigate any potential concerns.